https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977684/ https://www.ncbi.nlm.nih.gov/pubmed/24690202 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3977684/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495382/